(19)

(11)

EP 0 725 933 A1

(12)

(43) Date of publication: 14.08.1996 Bulletin 1996/33 (21) Application number: 95902405.0 (22) Date of filing: 26.10.1994

(51) International Patent Classification (IPC):  G01N 33/ 569( . ) G01N 33/ 86( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1994/012369 (87) International publication number: WO 1995/012125 (04.05.1995 Gazette 1995/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.10.1993 US A 142766 25.10.1994 US A 328475 (71) Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Rochester, MN 55905 (US) Kottke, Bruce A. Lakeland, FL 33803 (US) Wen, Deyong Rochester, MN 55902 (US)	(72) Inventors: KOTTKE, Bruce, A. Lakeland, FL 33803 (US) WEN, Deyong Rochester, MN 55902 (US) (74) Representative: Findlay, Alice Rosemary  Lloyd Wise, Tregear & Co., Commonwealth House, 1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)