(19)

(11)

EP 0 726 708 A1

(12)

(43) Date of publication: 21.08.1996 Bulletin 1996/34 (21) Application number: 95901761.0 (22) Date of filing: 04.11.1994

(51) International Patent Classification (IPC):  A61K 31/ 52( . ) C07K 14/ 03( . ) C12Q 1/ 70( . ) A61K 31/ 675( . ) C12N 15/ 12( . ) (86) International application number: PCT/US1994/012655 (87) International publication number: WO 1995/012313 (11.05.1995 Gazette 1995/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.11.1993 US 19930149176 24.03.1994 US 19940218029 05.08.1994 US 19940287942 04.11.1994 US 19940334482 (71) Applicant: PATHOGENESIS CORPORATION Seattle, WA 98119 (US)

(72) Inventors: BURMER, Glenna, C. Seattle, WA 98115 (US) CHALLONER, Peter, B. Seattle, WA 98109 (US) SMITH, Kirsten, T. Renton, WA 98056 (US) BROWN, Joseph, P. Seattle, WA 98119 (US) PARKER, Jay, D. Seattle, WA 98117 (US) NOWINSKI, Robert, C. Edmonds, WA 98020 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)