(19)

(11)

EP 0 729 458 A1

(12)

(43) Date of publication: 04.09.1996 Bulletin 1996/36 (21) Application number: 94901631.0 (22) Date of filing: 19.11.1993

(51) International Patent Classification (IPC):  A61K 31/ 47( . ) A61P 25/ 00( . ) A61P 25/ 20( . ) C07D 409/ 06( . ) A61K 31/ 473( . ) A61P 25/ 18( . ) C07D 221/ 10( . ) (86) International application number: PCT/US1993/011302 (87) International publication number: WO 1995/014006 (26.05.1995 Gazette 1995/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicants: THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS Providence, RI 02908 (US) Froimowitz, Mark Newton, MA 02159 (US)	(72) Inventors: FROIMOWITZ, Mark Newton, MA 02159 (US) JACOB, James, N. Saunders Town, RI 02874 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)