(19)

(11)

EP 0 730 405 A1

(12)

(43) Date of publication: 11.09.1996 Bulletin 1996/37 (21) Application number: 95902642.0 (22) Date of filing: 17.11.1994

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61K 47/ 16( . ) C07C 279/ 08( . ) C12N 15/ 88( . ) A61K 9/ 127( . ) A61K 48/ 00( . ) C12N 15/ 09( . ) (86) International application number: PCT/US1994/013428 (87) International publication number: WO 1995/014381 (01.06.1995 Gazette 1995/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.11.1993 US 19930157727 24.05.1994 US 19940248005 (71) Applicant: MEGABIOS CORPORATION Burlingame, CA 94010 (US)	(72) Inventors: HEATH, Timothy, D. Madison, WI 53705 (US) SOLODIN, Igor Madison, WI 53703 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)