(19)

(11)

EP 0 730 595 A1

(12)

(43) Date of publication: 11.09.1996 Bulletin 1996/37 (21) Application number: 95901942.0 (22) Date of filing: 18.11.1994

(51) International Patent Classification (IPC):  A61K 31/ 395( . ) C07D 487/ 04( . ) A61P 25/ 20( . ) (86) International application number: PCT/US1994/013325 (87) International publication number: WO 1995/014693 (01.06.1995 Gazette 1995/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 22.11.1993 US 19930156210 (71) Applicant: Merck & Co., Inc. Rahway New Jersey 07065-0900 (US)	(72) Inventors: BOCK, Mark, G. Rahway, NJ 07065 (US) FREIDINGER, Roger, M. Rahway, NJ 07065 (US) DIPARDO, Robert, M. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James, et al  European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)