(19)

(11)

EP 0 731 697 A1

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(43) Date of publication: 18.09.1996 Bulletin 1996/38 (21) Application number: 95904123.0 (22) Date of filing: 23.11.1994

(51) International Patent Classification (IPC):  A61K 31/ 275( . ) A61P 11/ 00( . ) A61P 29/ 00( . ) A61P 31/ 06( . ) A61P 43/ 00( . ) C07C 255/ 41( . ) A61P 9/ 10( . ) A61P 17/ 00( . ) A61P 31/ 04( . ) A61P 37/ 00( . ) C07C 255/ 40( . ) (86) International application number: PCT/US1994/013535 (87) International publication number: WO 1995/014464 (01.06.1995 Gazette 1995/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.11.1993 IL 19930107736 (71) Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM Jerusalem 91042 (IL) Kupot- Holim Health Insurance Institute of the General Federation of Labour in Eretz-Israel Tel-Aviv (IL) LEVITZKI, Alexander Patomic, MA 20854 (US)	(72) Inventors: LEVITZKI, Alexander Patomic, MA 20854 (US) NOVOGRODSKY, Abraham 76469 Rehovot (IL) GAZIT, Aviv Jerusalem (IL) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)