(19)

(11)

EP 0 733 102 A1

(12)

(43) Date of publication: 25.09.1996 Bulletin 1996/39 (21) Application number: 95902688.0 (22) Date of filing: 22.11.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C12N 5/ 00( . ) C12N 5/ 20( . ) C12P 21/ 08( . ) G01N 33/ 577( . ) C12R 1/ 91( . ) C07K 16/ 44( . ) C12N 5/ 10( . ) C12N 15/ 02( . ) G01N 33/ 533( . ) G01N 33/ 94( . ) (86) International application number: PCT/US1994/013558 (87) International publication number: WO 1995/016026 (15.06.1995 Gazette 1995/25)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI NL (30) Priority: 10.12.1993 US 19930165121 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: TYNER, Joan D. Beach Park, IL 60087 (US) JUVELAND, Sherri L. McHenry, IL 60050 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)