(19)

(11)

EP 0 734 201 A1

(12)

(43) Date of publication: 02.10.1996 Bulletin 1996/40 (21) Application number: 95901576.0 (22) Date of filing: 28.11.1994

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C07K 14/ 74( . ) C12N 15/ 85( . ) C07K 14/ 73( . ) C12N 15/ 09( . ) (86) International application number: PCT/IB1994/000417 (87) International publication number: WO 1995/014377 (01.06.1995 Gazette 1995/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.11.1993 US 19930158677 (71) Applicant: AMGEN CANADA INC. Missisauga, Ontario L5N 6J5 (CA)	(72) Inventors: YEUNG, Rae, Suk-Man Willowdale, Ontario M2K 2W5 (CA) MAK, Tak, W Toronto, Ontario M4W 2W3 (CA) (74) Representative: Silveston, Judith, et al  ABEL & IMRAY Northumberland House 303-306 High Holborn London, WC1V 7LH London, WC1V 7LH (GB)