(19)

(11)

EP 0 734 440 A1

(12)

(43) Date of publication: 02.10.1996 Bulletin 1996/40 (21) Application number: 95905906.0 (22) Date of filing: 14.12.1994

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61K 48/ 00( . ) C12N 15/ 12( . ) A61K 45/ 00( . ) C12N 5/ 16( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1994/014297 (87) International publication number: WO 1995/016775 (22.06.1995 Gazette 1995/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.12.1993 US 19930167464 16.06.1994 US 19940260547 (71) Applicants: Guo, Yajun Shaker Heights, OH 44120 (US) TYKOCINSKI, Mark L. Shaker Heights, OH 44122 (US)	(72) Inventors: Guo, Yajun Shaker Heights, OH 44120 (US) TYKOCINSKI, Mark L. Shaker Heights, OH 44122 (US) (74) Representative: Moon, Donald Keith, et al  BREWER & SON Quality House Quality Court Chancery Lane London WC2A 1HT London WC2A 1HT (GB)