(19)

(11)

EP 0 735 857 A1

(12)

(43) Date of publication: 09.10.1996 Bulletin 1996/41 (21) Application number: 94905498.0 (22) Date of filing: 21.12.1993

(51) International Patent Classification (IPC):  A61K 8/ 44( . ) A61Q 17/ 04( . ) A61K 8/ 49( . ) A61Q 19/ 04( . ) (86) International application number: PCT/US1993/012521 (87) International publication number: WO 1995/017161 (29.06.1995 Gazette 1995/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA Norman, Oklahoma 73019 (US)	(72) Inventor: FULLER, Bryan B. Edmond, OK 73013 (US) (74) Representative: Baillie, Iain Cameron, et al  c/o Ladas & Parry Altheimer Eck 2 80331 München 80331 München (DE)