(19)

(11)

EP 0 735 878 A1

(12)

(43) Date of publication: 09.10.1996 Bulletin 1996/41 (21) Application number: 95905068.0 (22) Date of filing: 14.12.1994

(51) International Patent Classification (IPC):  C07D 473/ 18( . ) A61K 31/ 522( . ) C07D 473/ 00( . ) A61K 31/ 52( . ) A61P 31/ 12( . ) (86) International application number: PCT/EP1994/004163 (87) International publication number: WO 1995/017190 (29.06.1995 Gazette 1995/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 22.12.1993 GB 19930026177 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: BOON, Ronald James, SmithKline Beecham Pharmac., Harlow, Essex CM 19 5AG (GB) GRIFFIN, David Ronald John Science Park South Harlow Essex CM19 5AG (GB) (74) Representative: Tocher, Pauline  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)