(19)

(11)

EP 0 736 008 A1

(12)

(43) Date of publication: 09.10.1996 Bulletin 1996/41 (21) Application number: 95904514.0 (22) Date of filing: 23.12.1994

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61K 31/ 404( . ) A61P 7/ 02( . ) A61P 43/ 00( . ) C07D 209/ 12( . ) A61K 31/ 403( . ) A61K 31/ 405( . ) A61P 35/ 00( . ) C07D 209/ 10( . ) C07D 403/ 06( . ) (86) International application number: PCT/EP1994/004250 (87) International publication number: WO 1995/017383 (29.06.1995 Gazette 1995/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.12.1993 GB 19930026332 (71) Applicant: KARO BIO AB S-141 04 Huddinge (SE)	(72) Inventor: NORINDER, Ulf S-141 Huddinge (SE) (74) Representative: Dean, John Paul  Withers & Rogers 4 Dyer's Buildings Holborn London EC1N 2JT London EC1N 2JT (GB)