(19)

(11)

EP 0 736 098 A1

(12)

(43) Date of publication: 09.10.1996 Bulletin 1996/41 (21) Application number: 95906122.0 (22) Date of filing: 23.12.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 31/ 04( . ) C07K 14/ 35( . ) C12N 5/ 10( . ) C12N 15/ 31( . ) C12N 15/ 74( . ) G01N 33/ 53( . ) C12R 1/ 32( . ) A61K 39/ 04( . ) A61P 31/ 06( . ) C12N 1/ 21( . ) C12N 15/ 00( . ) C12N 15/ 63( . ) C12Q 1/ 68( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1994/014912 (87) International publication number: WO 1995/017511 (29.06.1995 Gazette 1995/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.12.1993 NZ 19930250584 24.02.1994 US 19940201880 24.06.1994 US 19940265579 18.08.1994 US 19940292695 (71) Applicants: AGRESEARCH NEW ZEALAND PASTORAL AGRICULTURE RESEARCH INSTITUTE, LTD. Upper Hut (NZ) ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY Upper Hut (NZ)	(72) Inventors: JACOBS, William, R., Jr. City Island, NY 10464 (US) BLOOM, Barry, R. Hastings-on-Hudson, NY 10706 (US) COLLINS, Desmond M. Wellington (NZ) DE LISLE, Geoffrey W. Wellington (NZ) PASCOPELLA, Lisa Hamilton, MT 59840 (US) KAWAKAMI, Riku P. Wellington (NZ) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)