(19)

(11)

EP 0 736 179 A1

(12)

(43) Date of publication: 09.10.1996 Bulletin 1996/41 (21) Application number: 95906085.0 (22) Date of filing: 20.12.1994

(51) International Patent Classification (IPC):  G01N 33/ 569( . ) C07K 7/ 08( . ) C07K 7/ 06( . ) C07K 14/ 15( . ) (86) International application number: PCT/US1994/014815 (87) International publication number: WO 1995/017678 (29.06.1995 Gazette 1995/27)

(84) Designated Contracting States: AT BE DE ES FR GB IT NL SE (30) Priority: 20.12.1993 US 19930170063 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: SHIH, Jessie, W. Lake Forest, IL 60045 (US) BURCZAK, John, D. Highland Park, IL 60035 (US) LEE, Helen, H. Lake Forest, IL 60045 (US) O'DONNELL, Debra, L. Antioch, IL 60002 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)