(19)

(11)

EP 0 738 154 A1

(12)

(43) Date of publication: 23.10.1996 Bulletin 1996/43 (21) Application number: 94924100.0 (22) Date of filing: 29.07.1994

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 5/ 12( . ) A61P 5/ 32( . ) A61P 13/ 08( . ) A61P 15/ 08( . ) A61P 25/ 04( . ) C07K 7/ 06( . ) C07K 7/ 23( . ) A61P 5/ 04( . ) A61P 5/ 28( . ) A61P 13/ 02( . ) A61P 15/ 00( . ) A61P 15/ 18( . ) A61P 35/ 00( . ) C07K 7/ 08( . ) (86) International application number: PCT/US1994/008678 (87) International publication number: WO 1995/004541 (16.02.1995 Gazette 1995/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.08.1993 US 19930103022 27.07.1994 US 19940279677 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: HAVIV, Fortuna Deerfield, IL 60015 (US) FITZPATRICK, Timothy D. Boulder, CO 80304 (US) SWENSON, Rolf E. Grayslake, IL 60030 (US) NICHOLS, Charles, J. Greendale, WI 53129 (US) MORT, Nicholas A. Waukegan, IL 60085 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)