(19)

(11)

EP 0 739 345 A1

(12)

(43) Date of publication: 30.10.1996 Bulletin 1996/44 (21) Application number: 95904653.0 (22) Date of filing: 06.01.1995

(51) International Patent Classification (IPC):  A61K 31/ 395( . ) A61P 31/ 12( . ) C07D 273/ 00( . ) A61K 31/ 439( . ) A61P 31/ 18( . ) C07D 519/ 00( . ) (86) International application number: PCT/GB1995/000019 (87) International publication number: WO 1995/018808 (13.07.1995 Gazette 1995/30)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IE IT LI LU NL PT SE (30) Priority: 11.01.1994 GB 19940000411 (71) Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY London EC1N 8JP (GB)	(72) Inventors: BRIDGER, Gary, James Bryn Mawr, PA 19010 (US) PADMANABHAN, Sreenivasan Exton, PA 19341 (US) SKERLJ, Renato, Tony No. F26 Bryn Mawr, PA 19010 (US) (74) Representative: Brewer, Leonard Stuart  Patents Department Johnson Matthey Technology Centre Blounts Court Sonning Common Reading Berkshire RG4 9NH Reading Berkshire RG4 9NH (GB)