(19)

(11)

EP 0 740 667 A1

(12)

(43) Date of publication: 06.11.1996 Bulletin 1996/45 (21) Application number: 95901569.0 (22) Date of filing: 12.12.1994

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) A61P 31/ 04( . ) C07D 471/ 04( . ) A61K 31/ 4375( . ) C07D 209/ 00( . ) (86) International application number: PCT/IB1994/000410 (87) International publication number: WO 1995/019361 (20.07.1995 Gazette 1995/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 18.01.1994 US 19940181942 (71) Applicant: PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventors: BRAISH, Tamim, F. Ledyard, CT 06339 (US) FOX, Darrell, E. Pawcatuck, CT 06379 (US) NORRIS, Timothy Gales Ferry, CT 06335 (US) ROSE, Peter, R. Ledyard, CT 06339 (US) (74) Representative: Wood, David John, et al  PFIZER LIMITED, Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)