(19)
(11) EP 0 741 705 A1

(12)

(43) Date of publication:
13.11.1996 Bulletin 1996/46

(21) Application number: 95906531.0

(22) Date of filing: 27.01.1995
(51) International Patent Classification (IPC): 
A61K 31/ 4427( . )
A61K 31/ 451( . )
C07D 211/ 90( . )
 A61K 31/ 445( . )
A61P 9/ 12( . )
C07D 401/ 12( . )
(86) International application number:
PCT/JP1995/000100
(87) International publication number:
WO 1995/020576 (03.08.1995 Gazette 1995/33)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 29.01.1994 GB 19940001730
19.07.1994 GB 19940014563

(71) Applicants:
  • FUJISAWA PHARMACEUTICAL CO., LTD.
    Osaka-shi Osaka 541 (JP)
  • DAICEL CHEMICAL INDUSTRIES, LTD.
    Sakai-shi, Osaka 590 (JP)

(72) Inventors:
  • ITO,Kiyotaka Lions Mansion Akashihigashifutami 207
    Hyogo 674 (JP)
  • AKAMATSU, Hidekazu
    Arai-shi Niigata 944 (JP)
  • INOUE, Keizo
    Tsukuba-shi Ibaraki 300-32 (JP)
  • ONOMURA, Osamu
    Tsukuba-shi Ibaraki 305 (JP)
  • HAMATANI, Takeshi
    Tsukuba-shi Ibaraki 305 (JP)
  • UEDA, Yoichiro
    Tsukuba-shi Ibaraki 300-32 (JP)
  • ESUMI, Kimio
    Higashinada-ku Kobe-shi Hyogo 658 (JP)

(74) Representative: W.P. THOMPSON & CO. 
Eastcheap House Central Approach
Letchworth, Hertfordshire SG6 3DS
Letchworth, Hertfordshire SG6 3DS (GB)

   


(54) 4-(2-(3-ARYLOXY-2-HYDROXYPROPYLAMINO ALKYLOXY)-5-NITROPHENYL)-1,4-DIHYDROPYRIDINES AS ANTIHYPERTENSIVE AGENTS