(19)

(11)

EP 0 742 832 A1

(12)

(43) Date of publication: 20.11.1996 Bulletin 1996/47 (21) Application number: 95909483.0 (22) Date of filing: 02.02.1995

(51) International Patent Classification (IPC):  C12N 15/ 52( . ) C12N 15/ 74( . ) C12N 15/ 70( . ) C12P 7/ 62( . ) (86) International application number: PCT/US1995/001471 (87) International publication number: WO 1995/021260 (10.08.1995 Gazette 1995/34)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.02.1994 US 19940195481 (71) Applicant: CENTER FOR INNOVATIVE TECHNOLOGY Herndon, VA 22070 (US)	(72) Inventors: KIDWELL, John, P. Harrisonburg, VA 22801 (US) DENNIS, Douglas, E. Weyers Cave, VA 24486 (US) (74) Representative: Gowshall, Jonathan Vallance, et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 80801 München 80801 München (DE)