(19)

(11)

EP 0 743 839 A1

(12)

(43) Date of publication: 27.11.1996 Bulletin 1996/48 (21) Application number: 95910167.0 (22) Date of filing: 09.02.1995

(51) International Patent Classification (IPC):  A61F 2/ 02( . ) A61F 11/ 04( . ) A61N 1/ 32( . ) A61F 11/ 00( . ) A61N 1/ 05( . ) A61N 1/ 36( . ) (86) International application number: PCT/US1995/001391 (87) International publication number: WO 1995/021591 (17.08.1995 Gazette 1995/35)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 09.02.1994 US 19940194017 01.11.1994 US 19940332757 01.11.1994 US 19940332755 (71) Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION Iowa City, IA 52242 (US)	(72) Inventors: HOWARD, Matthew, A., III. Iowa City, IA 52246 (US) McCULLOCH, Timothy, M. Iowa City, IA 52246 (US) BAUER, Carol, A. Houston, TX 77056 (US) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)