(19)

(11)

EP 0 743 859 A1

(12)

(43) Date of publication: 27.11.1996 Bulletin 1996/48 (21) Application number: 95904098.0 (22) Date of filing: 16.11.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 7088( . ) A61K 49/ 00( . ) C07H 21/ 00( . ) C12N 15/ 113( . ) A61K 31/ 70( . ) A61K 48/ 00( . ) A61P 43/ 00( . ) C07H 21/ 04( . ) (86) International application number: PCT/US1994/013387 (87) International publication number: WO 1995/013834 (26.05.1995 Gazette 1995/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.11.1993 US 19930154013 16.11.1993 US 19930154014 26.04.1994 US 19940233778 04.05.1994 US 19940238177 (71) Applicant: GENTA INCORPORATED San Diego, California 92121 (US)	(72) Inventors: ARNOLD, Lyle J., Jr. Poway, CA 92064 (US) REYNOLDS, Mark A. San Diego, CA 92130 (US) GIACHETTI, Christina Solana Beach, CA 92075 (US) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)