(19)
(11) EP 0 745 128 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.07.2004 Bulletin 2004/29

(45) Mention of the grant of the patent:
29.10.2003 Bulletin 2003/44

(21) Application number: 94917325.6

(22) Date of filing: 09.05.1994
(51) International Patent Classification (IPC)7: C12N 15/51, C12N 1/21, C12N 5/10, C12N 7/00, C12P 21/00, A61K 39/29, C12Q 1/70, C12Q 1/68, C07K 14/08
(86) International application number:
PCT/US1994/005090
(87) International publication number:
WO 1994/026904 (24.11.1994 Gazette 1994/26)

(54)

HEPATITIS B VIRUS MUTANTS, REAGENTS AND METHODS FOR DETECTION

HEPATITIS-B-VIRUSMUTANTEN, UND VERBINDUNGEN UND VERFAHREN FÜR IHRE BESTIMMUNG

MUTANTS DU VIRUS DE L'HEPATITE B, REACTIFS ET PROCEDES DE DETECTION

(84) Designated Contracting States:
BE CH DE ES FR GB IT LI

(30) Priority: 07.05.1993 US 59031

(43) Date of publication of application:
04.12.1996 Bulletin 1996/49

(73) Proprietors:
  • ABBOTT LABORATORIES
    Abbott Park, Illinois 60064-3500 (US)
  • The University Court of the University of Glasgow
    Glasgow G12 8QQ (GB)

(72) Inventors:
  • CARMAN, William
    Glasglow G42 8QN (GB)
  • DECKER, Richard H.
    Deerfield, IL 60015 (US)
  • WALLACE, Lesley
    Thornwood Glasgow G11 7XE (GB)
  • MIMMS, Larry T.
    Lake Villa, IL 60046 (US)
  • SOLOMON, Larry R.
    Mundelein, IL 60060 (US)

(74) Representative: Modiano, Guido, Dr.-Ing. et al
Modiano, Josif, Pisanty & Staub, Baaderstrasse 3
80469 München
80469 München (DE)


(56) References cited: : 
WO-A-95/21189
   
  • GASTROENTEROLOGY, Volume 102, issued 1992, CARMAN et al., "Genetic Variation in Hepatitis B Virus", pages 711-719.
  • JOURNAL OF VIROLOGY, Volume 68, No. 4, issued April 1994, YAMAMOTO et al., "Naturally Occurring Escape Mutants of Hepatitis B Virus with Various Mutations in the S Gene in Carriers Seropositive for Antibody to Hepatitis B Surface Antigen", pages 2671-2676.
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).