(19)

(11)

EP 0 746 542 A1

(12)

(43) Date of publication: 11.12.1996 Bulletin 1996/50 (21) Application number: 95909037.0 (22) Date of filing: 23.02.1995

(51) International Patent Classification (IPC):  A61K 31/ 275( . ) A61P 31/ 12( . ) C07C 315/ 04( . ) C07C 319/ 14( . ) C07C 323/ 65( . ) A61P 29/ 00( . ) C07C 315/ 02( . ) C07C 317/ 48( . ) C07C 323/ 63( . ) (86) International application number: PCT/GB1995/000376 (87) International publication number: WO 1995/023134 (31.08.1995 Gazette 1995/37)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT SI (30) Priority: 23.02.1994 GB 19940003408 (71) Applicant: THE WELLCOME FOUNDATION LIMITED Greenford, Middlesex UB6 0NN (GB)	(72) Inventor: CHAN, Joseph, Howing Chapel Hill, NC 27514 (US) (74) Representative: Quillin, Helen Kaye, et al  Glaxo Wellcome plc Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)