(19)
(11) EP 0 746 609 A1

(12)

(43) Date of publication:
11.12.1996 Bulletin 1996/50

(21) Application number: 93901143.0

(22) Date of filing: 17.12.1992
(51) International Patent Classification (IPC): 
A01K 67/ 027( . )
C07K 16/ 28( . )
C07K 16/ 42( . )
C12N 5/ 10( . )
C12N 15/ 09( . )
C12N 15/ 90( . )
A61K 38/ 00( . )
 C07K 16/ 00( . )
C07K 16/ 30( . )
C07K 16/ 44( . )
C12N 15/ 02( . )
C12N 15/ 85( . )
C12P 21/ 08( . )
C12R 1/ 91( . )
(86) International application number:
PCT/US1992/010983
(87) International publication number:
WO 1993/012227 (24.06.1993 Gazette 1993/15)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 17.12.1991 US 19910810279
18.03.1992 US 19920853408
23.06.1992 US 19920904068

(60) Divisional application:
02079536.5 / 1288229

(71) Applicant: GENPHARM INTERNATIONAL
Mountain View, CA 94043 (US)

(72) Inventors:
  • LONBERG, Nils
    San Francisco, CA 94117 (US)
  • KAY, Robert M.
    San Francisco, CA 94115 (US)

(74) Representative: Bizley, Richard Edward, et al 
Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane
Epping Essex CM16 5DQ
Epping Essex CM16 5DQ (GB)

   


(54) TRANSGENIC NON-HUMAN ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES