| (84) |
Designated Contracting States: |
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DE FR GB |
| (30) |
Priority: |
09.02.1994 US 193829
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| (43) |
Date of publication of application: |
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18.12.1996 Bulletin 1996/51 |
| (73) |
Proprietors: |
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- Sugen, Inc.
Redwood City, CA 94063 (US)
- YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
Jerusalem 91042 (IL)
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| (72) |
Inventors: |
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- GAZIT, Aviv
96190 Jerusalem (IL)
- LEVITZKI, Alexander
Patomic, MA 02854 (US)
- APP, Harald
Hillsborough, CA 94010 (US)
- TANG, Cho, Peng
Moraga, CA 94556 (US)
- MCMAHON, Gerald, M.
San Francisco, CA 94109 (US)
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| (74) |
Representative: Jaenichen, Hans-Rainer, Dr. |
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Vossius & Partner,
Postfach 86 07 67
81634 München
81634 München (DE) |
| (56) |
References cited: :
EP-A- 0 520 722
WO-A-95/19169
JP-A- 55 167 205
|
EP-A- 0 665 013
DE-B- 1 135 471
JP-A- 60 097 964
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- J. MED. CHEM., Volume 26, issued 1983, STOUT et al., "Synthesis and Antiarrhythmic
and Parasympatholytic Properties of Substituted Phenols. 1. Heteroarylamine Derivatives",
pages 808-813.
- CHEMICAL ABSTRACTS, Volume 117, issued 1990, KOKOSI et al., "Process for Producing
Imidazo[5,1-Beta]Quinazolin-9-one Derivatives and Pharmaceutically Acceptable Salts
Thereof, as well as Pharmaceutical Compositions Comprising such as Active Ingredient",
Abstract No. 212519; & HU,A, 59 411.
- ANTI-CANCER DRUGS, Volume 5, issued 1994, KAUR et al., "Tyrphostin Induced Growth
Inhibition: Correlation with Effect on P210 bcr-abl Autokinase Activity in K562 Chronic
Myelogenous Leukemia", pages 213-222.
- JOURNAL F. PRAKT. CHEM., Volume 329, No. 1, issued 1987, VOGEL et al., "Synthese von
4-Substituierten 1,2,3-Triazolo[1,5-a]-Chinoxalinen", pages 101-107.
- JOURNAL OF MEDICINAL CHEMISTRY, Volume 36, issued 1993, GAZIT et al., "Tyrphostins.
3. Structure-Activity Relationship Studies of Alpha-Substituted Benzylidenemalononitrile
5-S-Aryltyrphostins", pages 3556-3564.
- BIOCHEMISTRY, Volume 32, No. 17, issued 1993, OHMICHI et al., "The Tyrosine Kinase
Inhibitor Tyrphostin Blocks the Cellular Actions of Nerve Growth Factor", pages 4650-4658.
- BIOCHIMICA ET BIOPHYSICA ACTA, Volume 935, issued 1988, MIYOSHI et al., "Quantitative
Analysis of the Uncoupling Activity of Substituted Phenols with Mitochondria from
Flight Muscles of House Flies", pages 312-321.
- CANADIAN JOURNAL OF CHEMISTRY, Volume 63, issued 1985, MARLIN, "Resonance Raman Study
of Phenylhydrazonopropanedinitriles", pages 1840-1844.
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