(19)

(11)

EP 0 748 333 A1

(12)

(43) Date of publication: 18.12.1996 Bulletin 1996/51 (21) Application number: 95911134.0 (22) Date of filing: 03.03.1995

(51) International Patent Classification (IPC):  C07D 401/ 12( . ) A61K 31/ 42( . ) A61K 31/ 44( . ) A61K 31/ 47( . ) A61P 7/ 02( . ) C07D 403/ 12( . ) C07D 417/ 12( . ) C07K 5/ 078( . ) C07K 5/ 087( . ) A61K 38/ 00( . ) A61K 31/ 40( . ) A61K 31/ 425( . ) A61K 31/ 4427( . ) A61K 38/ 55( . ) C07D 207/ 16( . ) C07D 413/ 12( . ) C07K 5/ 065( . ) C07K 5/ 083( . ) C07K 14/ 47( . ) (86) International application number: PCT/US1995/002627 (87) International publication number: WO 1995/023809 (08.09.1995 Gazette 1995/38)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT SI (30) Priority: 04.03.1994 US 19940206500 05.10.1994 US 19940318600 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: SCHACHT, Aaron Leigh Indianapolis, IN 46278 (US) SHUMAN, Robert Theodore Greenwood, IN 46143 (US) SMITH, Gerald Floyd Indianapolis, IN 46217 (US) WIKEL, James Howard Greenwood, IN 46142 (US) WILEY, Michael Robert Indianapolis, IN 46268 (US) (74) Representative: Hudson, Christopher Mark  Lilly Industries Limited European Patent Operations Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)