(19)

(11)

EP 0 748 447 A1

(12)

(43) Date of publication: 18.12.1996 Bulletin 1996/51 (21) Application number: 95912625.0 (22) Date of filing: 28.02.1995

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) G01N 33/ 564( . ) A61K 39/ 395( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1995/002426 (87) International publication number: WO 1995/023970 (08.09.1995 Gazette 1995/38)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.03.1994 IL 19940108789 28.06.1994 IL 19940110142 (71) Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. Rehovot 76100 (IL)	(72) Inventors: SHINITZKY, Meir 49610 Kfar Shmaryahu (IL) DECKMANN, Michael F-68500 Guebwiller (FR) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)