(19)

(11)

EP 0 749 313 A1

(12)

(43) Date of publication: 27.12.1996 Bulletin 1996/52 (21) Application number: 95914014.0 (22) Date of filing: 10.03.1995

(51) International Patent Classification (IPC):  C07D 239/ 26( . ) A61K 31/ 403( . ) A61K 31/ 42( . ) A61K 31/ 437( . ) A61K 31/ 4418( . ) A61K 31/ 475( . ) A61K 31/ 495( . ) A61K 31/ 505( . ) A61P 1/ 10( . ) A61P 9/ 08( . ) A61P 11/ 00( . ) A61P 15/ 00( . ) C07D 209/ 14( . ) C07D 209/ 60( . ) C07D 261/ 08( . ) C07D 295/ 096( . ) C07D 401/ 12( . ) C07D 471/ 06( . ) A61K 31/ 40( . ) A61K 31/ 404( . ) A61K 31/ 435( . ) A61K 31/ 44( . ) A61K 31/ 4427( . ) A61K 31/ 48( . ) A61K 31/ 496( . ) A61K 31/ 55( . ) A61P 1/ 12( . ) A61P 9/ 10( . ) A61P 13/ 02( . ) A61P 43/ 00( . ) C07D 209/ 16( . ) C07D 213/ 65( . ) C07D 261/ 10( . ) C07D 307/ 81( . ) C07D 471/ 04( . ) (86) International application number: PCT/US1995/003099 (87) International publication number: WO 1995/024200 (14.09.1995 Gazette 1995/39)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT SI (30) Priority: 11.03.1994 US 19940212622 06.02.1995 US 19950380566 06.02.1995 US 19950380565 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: AUDIA, James Edmund Indianapolis, IN 46278 (US) COHEN, Marlene Lois Carmel, IN 46032 (US) GIDDA, Jaswant Singh Carmel, IN 46032 (US) NELSON, David Lloyd Garver Carmel, IN 46033 (US) BAKER, Stephen Richard Yateley, Camberley, Surrey GU17 7DQ (GB) EZQUERRA-CARRERA, Jesus E-28003 Madrid (ES) LAMAS-PETEIRA, Carlos E-28020 Madrid (ES) PEDREGAL-TERCERO, Concepcion E-28016 Madrid (ES) (74) Representative: Hudson, Christopher Mark, et al  Lilly Industries Limited European Patent Operations Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)