(19)

(11)

EP 0 750 670 A1

(12)

(43) Date of publication: 02.01.1997 Bulletin 1997/01 (21) Application number: 95909517.0 (22) Date of filing: 06.02.1995

(51) International Patent Classification (IPC):  C07K 14/ 055( . ) A61K 39/ 00( . ) C12N 15/ 38( . ) (86) International application number: PCT/US1995/001615 (87) International publication number: WO 1995/021255 (10.08.1995 Gazette 1995/34)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.02.1994 US 19940192633 (71) Applicant: CORNELL RESEARCH FOUNDATION, INC. Ithaca, NY 14850 (US)	(72) Inventors: SCHAT, Karel A. Ithaca, NY 14850 (US) OHASHI, Kazuhiko Sapporo 060 (JP) O'CONNELL, Priscilla H. Ithaca, NY 14850 (US) (74) Representative: Schlich, George William, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)