(19)

(11)

EP 0 751 956 A1

(12)

(43) Date of publication: 08.01.1997 Bulletin 1997/02 (21) Application number: 95910704.0 (22) Date of filing: 20.03.1995

(51) International Patent Classification (IPC):  A61K 39/ 102( . ) C07K 14/ 195( . ) A61K 39/ 00( . ) A61P 31/ 04( . ) C07K 14/ 285( . ) (86) International application number: PCT/IB1995/000185 (87) International publication number: WO 1995/025742 (28.09.1995 Gazette 1995/41)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 22.03.1994 US 19940216202 (71) Applicant: PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventors: ANKENBAUER, Robert Gerard Lincoln, NE 68506 (US) DAYALU, Krishnaswamy Iyengar Lincoln, NE 68506 (US) ISAACSON, Wanda Kay Raymond, NE 68428 (US) KAUFMAN, Thomas James Lincoln, NE 68523 (US) LI, Wumin Lincoln, NE 68506 (US) PFEIFFER, Nancy Ellen Seward, NE 68434 (US) (74) Representative: Davies, Jonathan Mark  Reddie & Grose 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)