(19)

(11)

EP 0 751 989 A1

(12)

(43) Date of publication: 08.01.1997 Bulletin 1997/02 (21) Application number: 95910271.0 (22) Date of filing: 17.02.1995

(51) International Patent Classification (IPC):  C12N 9/ 00( . ) C12N 9/ 96( . ) (86) International application number: PCT/US1995/001927 (87) International publication number: WO 1995/022602 (24.08.1995 Gazette 1995/36)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.02.1994 US 19940198919 (71) Applicant: GENZYME CORPORATION Cambridge, Massachusetts 02139-1562 (US)	(72) Inventors: MAGNESON, Gerald R. Needham, MA 02192 (US) NAG, Sumatra Burlington, MA 01803 (US) (74) Representative: Froud, Clive, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)