(19)

(11)

EP 0 752 000 A1

(12)

(43) Date of publication: 08.01.1997 Bulletin 1997/02 (21) Application number: 95912349.0 (22) Date of filing: 24.03.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 35/ 76( . ) A61K 39/ 21( . ) A61P 31/ 12( . ) C12N 7/ 00( . ) A61K 31/ 70( . ) A61K 38/ 43( . ) A61K 48/ 00( . ) C07H 21/ 04( . ) C12N 15/ 867( . ) (86) International application number: PCT/GB1995/000663 (87) International publication number: WO 1995/025806 (28.09.1995 Gazette 1995/41)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 24.03.1994 GB 19940005876 24.03.1994 GB 19940005875 09.12.1994 GB 19940025026 (71) Applicant: SYNGENIX LIMITED GB-Cambridge CB3 0BL (GB)	(72) Inventors: LEVER, Andrew, Michael, Lindsay Cambridge CB1 4SL (GB) HARRISON, Geoffrey, Philip Dept. of Medicine Cambridge CB2 2QQ (GB) HUNTER, Eric The Univ. of Alabama at Birmingham University Station Birmingham, AL 3 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)