(19)

(11)

EP 0 752 856 A1

(12)

(43) Date of publication: 15.01.1997 Bulletin 1997/03 (21) Application number: 94915933.0 (22) Date of filing: 28.04.1994

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61P 3/ 06( . ) A61K 31/ 403( . ) C07D 209/ 54( . ) (86) International application number: PCT/US1994/004683 (87) International publication number: WO 1994/025024 (10.11.1994 Gazette 1994/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.04.1993 GB 19930008780 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: BADGER, Alison Mary Bryn Mawr, PA 19010 (US) (74) Representative: Summersell, Richard John, Dr.  SmithKline Beecham plc, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)