(19)

(11)

EP 0 753 060 A1

(12)

(43) Date of publication: 15.01.1997 Bulletin 1997/03 (21) Application number: 95916452.0 (22) Date of filing: 14.04.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 13( . ) A61K 38/ 00( . ) C07K 14/ 725( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1995/004803 (87) International publication number: WO 1995/028481 (26.10.1995 Gazette 1995/46)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.04.1994 US 19940229285 (71) Applicant: NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY New York, N.Y. 10021 (US)	(72) Inventors: FRIEDMAN, Steven, M. Tenafly, NJ 07670 (US) CROW, Mary, K. New York, NY 10128 (US) LI, Yixin New York, NY 10028 (US) TUMANG, Joseph, R. Woodhaven, NY 11421 (US) SUN, Guang-Rong New York, NY 10028 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)