(19)

(11)

EP 0 753 992 A1

(12)

(43) Date of publication: 22.01.1997 Bulletin 1997/04 (21) Application number: 95911802.0 (22) Date of filing: 16.02.1995

(51) International Patent Classification (IPC):  A01H 1/ 00( . ) C12N 15/ 82( . ) C12N 9/ 22( . ) (86) International application number: PCT/US1995/002058 (87) International publication number: WO 1995/022245 (24.08.1995 Gazette 1995/36)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.02.1994 US 19940198973 (71) Applicant: THE CLEVELAND CLINIC FOUNDATION Cleveland, OH 44195-5124 (US)	(72) Inventors: SILVERMAN, Robert H. Shaker Heights, OH 44122 (US) SENGUPTA, Dibyendu N. Shaker Heights, OH 44122 (US) (74) Representative: Findlay, Alice Rosemary, et al  Lloyd Wise, Tregear & Co., Commonwealth House, 1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)