(19)

(11)

EP 0 755 268 A1

(12)

(43) Date of publication: 29.01.1997 Bulletin 1997/05 (21) Application number: 95916281.0 (22) Date of filing: 10.04.1995

(51) International Patent Classification (IPC):  A61K 38/ 17( . ) A61K 38/ 22( . ) A61K 38/ 28( . ) A61K 38/ 36( . ) A61K 38/ 44( . ) A61K 38/ 48( . ) A61K 48/ 00( . ) A61K 38/ 00( . ) A61K 38/ 18( . ) A61K 38/ 27( . ) A61K 38/ 34( . ) A61K 38/ 37( . ) A61K 38/ 46( . ) A61K 38/ 57( . ) C07K 14/ 62( . ) (86) International application number: PCT/US1995/004397 (87) International publication number: WO 1995/027512 (19.10.1995 Gazette 1995/45)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.04.1994 US 19940225840 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)

(72) Inventors: WOO, Savio, L., C. Houston, TX 77096 (US) SMITH, Louis, C. Seabrook, TX 77586 (US) CHAN, Lawrence, C., B. Houston, TX 77071 (US) ROLLAND, Allain Houston, TX 77077 (US) KAY, Mark, A. Seattle, WA 98115 (US) EISENSMITH, Randy, C. Houston, TX 77025 (US) MOSS, Larry Boston, MA 02112 (US) KOLODKA, Tadeusz Houston, TX 77054 (US) HAHN, Tina, M. Friendswood, TX 77546 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)