(19)

(11)

EP 0 755 453 A1

(12)

(43) Date of publication: 29.01.1997 Bulletin 1997/05 (21) Application number: 95916343.0 (22) Date of filing: 10.04.1995

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C12N 15/ 09( . ) C12Q 1/ 25( . ) C12Q 1/ 70( . ) G01N 33/ 566( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) C12Q 1/ 68( . ) G01N 33/ 53( . ) (86) International application number: PCT/US1995/004511 (87) International publication number: WO 1995/028492 (26.10.1995 Gazette 1995/46)

(84) Designated Contracting States: DE ES FR GB IT (30) Priority: 14.04.1994 US 19940228934 27.03.1995 US 19950410780 (71) Applicant: LIGAND PHARMACEUTICALS, INC. San Diego, CA 92121 (US)	(72) Inventors: LAMB, I. Peter San Diego, CA 92121 (US) SEIDEL, H. Martin San Diego, CA 92122 (US) (74) Representative: Fürniss, Peter, Dr., et al  Kuhnen, Wacker & Partner Alois-Steinecker-Strasse 22 85354 Freising 85354 Freising (DE)