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(11)

EP 0 756 494 A1

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(43) Date of publication: 05.02.1997 Bulletin 1997/06 (21) Application number: 95920629.0 (22) Date of filing: 24.05.1995

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) C07K 14/ 65( . ) (86) International application number: PCT/US1995/006540 (87) International publication number: WO 1995/032003 (30.11.1995 Gazette 1995/51)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 24.05.1994 US 19940248273 (71) Applicant: AMGEN BOULDER INC. Boulder, CO 80301-2546 (US)	(72) Inventors: COX, George N. Louisville, CO 80227 (US) McDERMOTT, Martin J. Boulder, CO 80302 (US) KO, Christine Boulder, CO 80303 (US) (74) Representative: Brown, John David, et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 80801 München 80801 München (DE)