(19)

(11)

EP 0 756 629 A1

(12)

(43) Date of publication: 05.02.1997 Bulletin 1997/06 (21) Application number: 95915576.0 (22) Date of filing: 06.04.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 36( . ) C07K 14/ 415( . ) A61K 39/ 00( . ) A61K 38/ 00( . ) A61P 37/ 08( . ) C12N 5/ 10( . ) (86) International application number: PCT/US1995/004249 (87) International publication number: WO 1995/027786 (19.10.1995 Gazette 1995/45)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.04.1994 US 19940226248 06.12.1994 US 19940350225 (71) Applicant: IMMUNOLOGIC PHARMACEUTICAL CORPORATION Waltham, MA 02154 (US)

(72) Inventors: FRANZEN, Henry, M. Watertown, MA 02172 (US) POWERS, Stephen, Palmer Waltham, MA 02154 (US) KUO, Mei-chang Winchester, MA 01890 (US) EVANS, Sean Acton, MA 01720 (US) SHAKED, Ze'ev Berkeley, CA 94707 (US) CHEN, Xian North Chelmsford, MA 01863 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)