(19)
(11) EP 0 757 676 A1

(12)

(43) Date of publication:
12.02.1997 Bulletin 1997/07

(21) Application number: 95916636.0

(22) Date of filing: 12.04.1995
(51) International Patent Classification (IPC): 
A61K 31/ 435( . )
C07D 221/ 18( . )
A61P 35/ 00( . )
(86) International application number:
PCT/EP1995/001347
(87) International publication number:
WO 1995/029895 (09.11.1995 Gazette 1995/48)
(84) Designated Contracting States:
CH DE FR GB IT LI NL

(30) Priority: 28.04.1994 US 19940233998

(71) Applicant: KNOLL AKTIENGESELLSCHAFT
D-67061 Ludwigshafen (DE)

(72) Inventors:
  • FERNANDEZ BRANA, Miguel
    E-28036 Madrid (ES)
  • CASTELLANO BERLANGA, Jose Maria
    E-28036 Madrid (ES)
  • ROMERDAHL, Cynthia
    Wayland, MA 01778 (US)

(74) Representative: Karau, Wolfgang, Dr., et al 
BASF Aktiengesellschaft, Patentabteilung ZDX - C 6
67056 Ludwigshafen
67056 Ludwigshafen (DE)

   


(54) DIHYDRODIBENZO(DE,H)ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS