(19)

(11)

EP 0 759 077 A1

(12)

(43) Date of publication: 26.02.1997 Bulletin 1997/09 (21) Application number: 95917968.0 (22) Date of filing: 26.04.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 15/ 14( . ) C07H 21/ 04( . ) C12N 15/ 00( . ) C12P 21/ 02( . ) C12R 1/ 44( . ) A61K 38/ 00( . ) A61P 31/ 04( . ) C07K 14/ 31( . ) C12N 15/ 31( . ) C12R 1/ 19( . ) (86) International application number: PCT/EP1995/001587 (87) International publication number: WO 1995/030751 (16.11.1995 Gazette 1995/49)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.05.1994 GB 19940009200 21.12.1994 GB 19940025886 (71) Applicant: CIBA-GEIGY AG 4002 Basel (CH)	(72) Inventors: SURI, Bruno CH-4416 Budendorf (CH) PEEL, John, Edmondson CH-1470 Lully (CH) RASCHDORF, Fritz CH-4058 Basle (CH) SCHNEIDER, Josef D-79664 Wehr (DE)