(19)

(11)

EP 0 759 779 A1

(12)

(43) Date of publication: 05.03.1997 Bulletin 1997/10 (21) Application number: 95917987.0 (22) Date of filing: 02.05.1995

(51) International Patent Classification (IPC):  A61K 39/ 385( . ) A61K 47/ 48( . ) (86) International application number: PCT/EP1995/001661 (87) International publication number: WO 1995/029701 (09.11.1995 Gazette 1995/48)

(84) Designated Contracting States: CH DE FR GB IT LI SE (30) Priority: 03.05.1994 IL 19940109519 (71) Applicant: YEDA RESEARCH & DEVELOPMENT COMPANY, LTD. 76100 Rehovot (IL)	(72) Inventors: MIRELMAN, David 52960 Ramat-Efal (IL) MARKS, Robert S. 76300 Rehovot (IL) SELA, Michael 76100 Rehovot (IL) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)