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EP 0 759 938 A1

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(43) Date of publication: 05.03.1997 Bulletin 1997/10 (21) Application number: 95919759.0 (22) Date of filing: 08.05.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 47( . ) C07K 16/ 18( . ) A61K 38/ 00( . ) C07K 14/ 46( . ) C07K 14/ 475( . ) C12N 5/ 10( . ) A61K 48/ 00( . ) (86) International application number: PCT/US1995/005741 (87) International publication number: WO 1995/030693 (16.11.1995 Gazette 1995/49)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.05.1994 US 19940239228 (71) Applicant: Fred Hutchinson Cancer Research Center Seattle Washington 98104 (US)	(72) Inventors: WEINTRAUB, Harold M. +di - (US) LEE, Jacqueline E. Denver, CO 80209-4426 (US) HOLLENBERG, Stanley M. Portland, OR 97219 (US) TAPSCOTT, Stephen J. Seattle, WA 98144 (US) (74) Representative: Spall, Christopher John, et al  BARKER, BRETTELL & DUNCAN 138 Hagley Road Edgbaston Birmingham B16 9PW Edgbaston Birmingham B16 9PW (GB)