(19)

(11)

EP 0 760 101 A1

(12)

(43) Date of publication: 05.03.1997 Bulletin 1997/10 (21) Application number: 95920021.0 (22) Date of filing: 11.05.1995

(51) International Patent Classification (IPC):  G01N 27/ 327( . ) G01N 33/ 543( . ) (86) International application number: PCT/EP1995/001779 (87) International publication number: WO 1995/031725 (23.11.1995 Gazette 1995/50)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.05.1994 GB 19940009449 (71) Applicants: CAMBRIDGE LIFE SCIENCES PLC Ely Cambridgeshire CB7 4DT (GB) Byk Gulden Italia S.p.A. I-20100 Milano (IT)	(72) Inventors: MULLEN, William, Henry Grayslake, IL 60030 (US) KYLE, Nigel Cambridge, Cambridgeshire CB4 1RS (GB) LISSANDRELLO, Fabio I-20135 Milano (IT) (74) Representative: Rupp, Herbert, Dr., et al  c/o Byk Gulden Lomberg Chemische Fabrik GmbH Postfach 10 03 10 78403 Konstanz 78403 Konstanz (DE)