(19)

(11)

EP 0 763 022 A1

(12)

(43) Date of publication: 19.03.1997 Bulletin 1997/12 (21) Application number: 95921759.0 (22) Date of filing: 24.05.1995

(51) International Patent Classification (IPC):  C07D 279/ 12( . ) A61K 31/ 445( . ) A61K 31/ 5375( . ) A61P 3/ 14( . ) A61P 9/ 08( . ) A61P 25/ 00( . ) A61P 25/ 08( . ) A61P 25/ 30( . ) C07D 265/ 30( . ) A61K 31/ 42( . ) A61K 31/ 535( . ) A61P 3/ 00( . ) A61P 9/ 00( . ) A61P 9/ 10( . ) A61P 25/ 04( . ) A61P 25/ 28( . ) C07D 211/ 22( . ) (86) International application number: PCT/EP1995/002003 (87) International publication number: WO 1995/033723 (14.12.1995 Gazette 1996/01)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 02.06.1994 GB 19940011045 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: BROWN, Thomas, Henry, SmithKline Beecham Pharm. Harlow, Essex CM19 5AD (GB) COPPER, David, Gwyn, SmithKline Beecham Pharm. Harlow, Essex CM19 5AD (GB) (74) Representative: Florence, Julia Anne  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)