PURIFICATION OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES USING DEAE 5PW ANION ION-EXCHANGE CHROMATOGRAPHY AND HYDROPHOBIC INTERACTION CHROMATOGRAPHY - Patent 0765334

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EP 0 765 334 A1

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(43)	Date of publication:
	02.04.1997 Bulletin 1997/14

(21)	Application number: 95925363.0

(22)	Date of filing: 30.06.1995

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International Patent Classification (IPC):

C07H 1/ 06^{( . )}

C07H 21/ 00^{( . )}

(86)	International application number:
	PCT/US1995/008175

(87)	International publication number:
	WO 1996/001268 (18.01.1996 Gazette 1996/04)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

05.07.1994 US 19940270582

(71)	Applicant: HYBRIDON, Inc.
	Worcester, Massachusetts 01605 (US)

(72)	Inventors:
	PUMA, Patricia Hudson, MA 01749 (US) DUFFEY, Dan Jefferson, MA 01522 (US) DAWIDCZYK, Paul Farmington, MA 01701 (US)

(74)	Representative: Vossius, Volker, Dr., et al
	Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5 81679 München 81679 München (DE)

(54)	PURIFICATION OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES USING DEAE 5PW ANION ION-EXCHANGE CHROMATOGRAPHY AND HYDROPHOBIC INTERACTION CHROMATOGRAPHY