(19)

(11)

EP 0 765 475 A1

(12)

(43) Date of publication: 02.04.1997 Bulletin 1997/14 (21) Application number: 95921363.0 (22) Date of filing: 15.05.1995

(51) International Patent Classification (IPC):  G01N 33/ 566( . ) G01N 33/ 15( . ) C12Q 1/ 68( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1995/006524 (87) International publication number: WO 1995/031722 (23.11.1995 Gazette 1995/50)

(84) Designated Contracting States: DE ES FR GB IT (30) Priority: 18.05.1994 US 19940245470 (71) Applicant: LIGAND PHARMACEUTICALS, INC. San Diego, CA 92121 (US)	(72) Inventors: HERMANN, Thomas Solana Beach, CA 92075 (US) PIKE, John, W. Encinitas, CA 92024 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)