(19)

(11)

EP 0 765 477 A1

(12)

(43) Date of publication: 02.04.1997 Bulletin 1997/14 (21) Application number: 95922224.0 (22) Date of filing: 05.06.1995

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07D 207/ 14( . ) C08F 8/ 00( . ) G01N 33/ 566( . ) C07B 61/ 00( . ) C07D 409/ 06( . ) G01N 33/ 15( . ) (86) International application number: PCT/US1995/007150 (87) International publication number: WO 1995/034813 (21.12.1995 Gazette 1996/02)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 14.06.1994 US 19940259594 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0903 (US)	(72) Inventors: GAITANOPOULOS, Dimitri, E. Eagleville, PA 19403 (US) WEINSTOCK, Joseph Ph nixville, PA 19460 (US) (74) Representative: Lawton, Peter Philip, et al  SmithKline Beecham plc, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)