(19)

(11)

EP 0 769 902 A1

(12)

(43) Date of publication: 02.05.1997 Bulletin 1997/18 (21) Application number: 95923864.0 (22) Date of filing: 14.06.1995

(51) International Patent Classification (IPC):  C12N 15/ 00( . ) A61K 38/ 45( . ) A61P 37/ 06( . ) C12N 9/ 10( . ) A61K 35/ 12( . ) A61K 48/ 00( . ) C12N 5/ 06( . ) (86) International application number: PCT/US1995/007554 (87) International publication number: WO 1995/034202 (21.12.1995 Gazette 1996/02)

(84) Designated Contracting States: DE ES FR GB GR IT NL (30) Priority: 15.06.1994 US 19940260201 21.07.1994 US 19940278282 (71) Applicants: ALEXION PHARMACEUTICALS, INC. New Haven, CT 06511 (US) THE AUSTIN RESEARCH INSTITUTE Heidelberg, Victoria 3084 (AU)	(72) Inventors: SANDRIN, Mauro, S. Brunswick, VIC 3056 (AU) FODOR, William, L. Madison, CT 06443 (US) ROTHER, Russell, P. Cheshire, CT 06410 (US) SQUINTO, Stephen, P. Bethany, CT 06524 (US) MCKENZIE, Ian, F., C. West Brunswick, VIC 3055 (AU) (74) Representative: Froud, Clive, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)