(19)

(11)

EP 0 770 086 A1

(12)

(43) Date of publication: 02.05.1997 Bulletin 1997/18 (21) Application number: 94923875.0 (22) Date of filing: 16.05.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 35/ 00( . ) C07H 21/ 04( . ) C07K 14/ 52( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) A61K 35/ 76( . ) A61K 39/ 395( . ) A61P 31/ 12( . ) A61P 37/ 04( . ) C07K 14/ 47( . ) C07K 16/ 18( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1994/005385 (87) International publication number: WO 1995/031468 (23.11.1995 Gazette 1995/50)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: L1, Haodong Gaithersburg, Maryland 20878 (US) FITZGERALD, Lisa, M. Germantown, MD 20876 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)